why is my nipt test inconclusive

I just retested yesterday since the company doesn't charge if it comes back inconclusive. Ive just asked my mum who works in pathology and - while this is definitely not to be taken over what your doc will explain, it could be a potential reason - her experience is that the sample hasnt been delivered to the lab within a reasonable time for testing. I'm sure that it's not a definitive, but I like getting the facts and this has helped me be a little more mentally prepared. They are up to 99% accurate for chromosomal abnormalities. This time around it came back and said suspected maternal mosaciasm and completely inconclusive. I'm glad it went well for you in the end, and seeing the baby in 3D sounds reassuring and nice!! Fingers crossed your 12 week scan comes back ok. It's a screening test offered during pregnancy to see if the fetus is at risk for having a chromosomal disorder like Down syndrome (trisomy 21), trisomy 18 (Edwards syndrome) and trisomy 13 (Patau syndrome). It's. to help the technology advance more with this newer test. No, I am a public patient. Prediction of other SCA was more accurate. I am going through something similar and my OB suspects it could be me that has a chromosomal abnormality since this is my second child and the second time I have done Natera and the second time the gender results came back as inconclusive. and mine came back at 3.7% and couldn't be read. Did you get a conclusive test result in the end? I had a healthy son in 2020 in which they could not determine the gender. Research suggests that about 5 percent of women get no result at all. Seems unfair to leave you in limbo not knowing. Here is a list of the most common questions we are asked. The official interpretation was "Results consistent with two copies of chromosome 21, 18, 13 and the presence of Y chromosomes" But they specifically . This educational content is not medical or diagnostic advice. Patients having this testing should know that NIPT results do not diagnose a genetic condition or give a yes/no answer, and should seek follow-up testing if appropriate. juliolovesme 2 yr. ago I'm so sorry to hear that! Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. I just got referred to McMaster as well with a high risk FTS scan/blood work. Same happened to us. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. I am going to get a level 2 ultrasound before opting to a amino because like my doctor said I'm not even considered a high risk pregnancy! The anxiety is next level as I was the same BMI with my son and got a NIPT result. I had my blood drawn for the NIPT test on 12/28. Ive done nipt through generations and Harmony both reputable brands and they would never give results with that low of a fraction, as it could come from contamination from say, the person drawing the bloods or the one analysing touching the tube to read results. Sounds right on the money, I got turned away for my first babys boot as it was a Friday an they send the test on the Monday and they said they would have it sitting there all weekend its not recommended. Please place POST FLAIR on your actual post. No problems and the procedure was not nearly as bad as I thought. NIPT is commonly used for chromosomal disorders that are caused by the presence of an extra (triploidy) or missing copy (aneuploidy) of a chromosome. Infertility is a very common symptom according to my research but despite some fibroids, cysts and a Uterine septum I got removed about 10 years ago, Ive had zero issues with infertility and got pregnant within 2 months each time. These are in different colors and allows users to actually click on the post flair and pull up every post that has a similar situation such as -no results-trisomy 13-NT scan question-etc. One such factor is high maternal weight. There are a few other reasons for odd results. Ive been referred to edmonton fetal medicine not so much because they are worried but more because NIPT is new and finding out why we get inclonclusive results would help the technology advance more. Thank you for sharing your personal story with me. I finally decided to do the Amnio yesterday and now anxiously waiting forresults and am so scare for her to even be Mosaic Turner. So sorry to hear that! I'm wondering if because I'm a plus size mother? I'm sure it's just there to drive us insane! But I wish you all the best! Update: I did the redraw and got my results back yesterday. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Someone please help calm my nerves! Good luckI hope all is well with baby! If you click on the green no results tag low FF youll find all the posts about this in the sub. Find advice, support and good company (and some stuff just for fun). I had both. It has to be at least above 4 percent to give a conclusive result. My OB says she sees it all the time and they usually resolve themselves. They said since they dont know which of my cells are missing the X because they only take a sample size, its hard to pinpoint what is impacted or not. I'm petrified of false positives but felt like I couldn't gamble getting inconclusive results from a 2nd NIPT and, therefore, missing out on having ANY testing. Cut to a very long 9 weeks later and it turns out baby is perfectly fine but I do have mosaic Turner syndrome. Science has produced many safe, medically sound, and accurate methods to determine the sex of a fetus during pregnancy. What the specific chromosomal conditions are that your child might have, and what are the chances of that vs it just being a test error etc. Anyone else have this come up? I'm sure that it's not a definitive, but I like getting the facts and this has helped me be a little more mentally prepared. When cells break down, they release . Im currently going through the exact same thing. Common Abnormalities Are: Down syndrome (trisomy 21 . Here are 3 factors that can lead to such a result. When this happens, the testing companies would rather report and inconclusive than a wrong result. you will see them all over the place here. In some cases, a test result might not give any useful information. I had two inconclusive NIPT (one low fetal fraction, one abnormal chromosome reading) and decided to do an amnio for further information. I'm not sure who it was but scroll back a bit and i'm sure you'll find it! Getting my blood redrawn tomorrow. I wish you and your baby boy all the best too! The cell-free DNA tests also screen for other chromosomal abnormalities other than Down's, such as Edward's syndrome. I'm waiting on my nipt test results now too. Hopefully will have before weds next week. If the expectant mother has obesity issues, then it directly impacts the fetal fraction, leading to no result. Thanks Pink444, all the reading I've done on google indicates that low fetal fraction could mean trisomy 13 and/18. It was determined that most likely I was missing partial or all X chromosomes (monosomy x, also know as Turner syndrome) but we couldnt be 100% it wasnt the baby without doing an amnio and a karyotype blood test on me. My NIPT came up inconclusive the first time as well. Both of these usually go away but I'm just worried! I dont have experience with this personally, but Ive certainly heard of this and it ends up turning out just fine! We are part of Sonic Healthcare, an acknowledged world leader in the provision of diagnostic services, and Australias largest pathology provider. I hope your quad screen is conclusive so you get some answers. I'll do my 3rd test at nearly 16 weeks. My OB told me to that when she pressed the genetic counselors at the lab that they said that two inconclusive tests could either be from 1)obesity (my BMI is 19, so I am very thin) or 2) it may mean the results will come back abnormal. In most cases, the results will say that a genetic condition is unlikely. ), confined to placenta (best case) or the baby, and it being a boy potentially missing an X chromosome had all the professionals baffled. why is my nipt test inconclusive. My intention is that you have as much information about what may be going on and can make informed decisions with your treatment team moving forward. What the heck, now so stressed! With my first daughter there was an ECF as well that resolved itself. It has to be at least above 4 percent to give a conclusive result. My NT ultrasound was normal but they didnt do the blood draw portion because I was getting the nipt, I should ask if they want to do that as well as I may be past the dates for the triple screen draw if I wait for results from my 2nd nipt, Im already 13+2. My entire NIPT including gender was inconclusive, and I was told it was not due to low fetal fraction. 5/23: 3rd beta: 4000.6 + saw gestational sac and yolk sac. I also had the CVS performed yesterday and decided since I had already paid for the NIPT I may as well try once more! Sorry youve gone through this stress xx. Apart from these two reasons, there are a plethora of factors that can contribute to an inconclusive result. I could have written this myself. Since the nIPT is inconclusive youll have this redrawn but in the mean time I would get the triple screen. There are 2 main sticky posts about what NIPT is, how it works, what it can miss and how false positives happen, sono findings, and your chances of a true positive after NIPT. Childhood-onset disorders due to new cytogenetic abnormalities and inherited mutations. Reasons behind an inconclusive prenatal paternity test. Nipt test inconclusive twice - Page 2: Has anyone had the test come out inconclusive twice? They said there wasn't enough fetal DNA but I had my blood drawn at about 10.5 weeks and then 12 weeks and it was still inconclusive! Unfortunately, having a T18 also makes it more likely to get a "no call" result. Symptmes de grossesse ne jamais ignorer, Moyens naturels pour dclencher l'accouchement. Acosta decided to take advantage of non-invasive pregnancy testing, or NIPT, a relatively new prenatal screening method. I met with a genetic counsellor who reviewed my file, age and risk, nd we decided together no further testing was needdd however for peace of mind and funsies we did the quad test which is a hormone test and can flag for trisonmies. Why genetic testing is bad? When did you have your NIPT done? Reasons behind an inconclusive prenatal paternity test. Yes. I have been feeling so worry and pessimistic ever since the NIPT result. Noninvasive prenatal testing (NIPT) has become a popular screening test for the most common fetal aneuploidies. I have passed my 1st trimester and 2nd trimester genetic screening tests as well as my NT scan during 12 week U/S. The #1 app for tracking pregnancy and baby growth. All rights reserved. Just pooping in about the initial ratio1:10000 is fabulous! Pregnancy. I hope this helps you consider an alternative, less stressful reason. Please specify a reason for deleting this reply from the community. 1997-2023 BabyCenter, LLC, a Ziff Davis company. Source: www.babycenter.com.au. Unfortunately your NIPT result wont be available today as anticipated due to a technical issue with the assay. If you have been incorrectly told that the accuracy of your result is 99% without a proper Predictive Value calculation please report this somewhere as this actually leads to wrongful terminations of pregnancies in that office. 20052023 BabyCenter, LLC, a Ziff Davis company. I would request PaPPa and hcg and NT screen which is the triple screen. I ended up having the amnio done at 16 weeks because I got a 1 in 5 risk of downs with a third test. So as others have said, keep the faith if your first test is inconclusive! Are you going to get retested? Your post will be hidden and deleted by moderators. The non-invasive prenatal test (NIPT) is an accurate screening test for common trisomies, sex chromosome aneuploidies and other selected chromosome abnormalities. Went back yesterday and did a redraw, and now I'm hoping this one takes. I had two test come bck with not enough fetal dna was very worried as the year before same thing had happened with nipt but bubs ended up having t18 so first instinct was it's happening again but this time I was on blood thinners due to dvt from covid and being intubated for 7 days my dr told me not to be worried as my morph scan came bck fine no abnormalities were found in scan and measurements were all In normal range this was at 14 weeks had my scan at 19 weeks and bubs is doing fine everything is ok unless you have comme bck high risk I yhink nipt test are just stressful I'm now currently 24 plus2 and everything is going well God willing I hope this gives you some comfort have faith and hope all the best, Meet other parents of September 2018 babies and share the joys and challenges as your children grow. That means whatever caused no result the first time is still interfering with the test. Almost 10 weeks of, this is a first for us and Ive never seen this before, we are doing further research made the first half or my pregnancy extremely tough. Have you gotten your NIPT results back yet? For some patients, however, results are not reported because of laboratory technical issues such as low fetal fraction and sequencing failures. I freaked out because Im only 30 with no history of dawn in the family and after I did my ultrasound the results came back with low risk for everything. Below this, the nipt returns the result "inconclusive." after the nipt results: Inconclusive sca an inconclusive sca. Not all physicians are actually up to date with NIPT testing, what results mean or how to present such SCREENING results to a patient. 3) anything that the NT scan would show (that NIPT wouldnt), the anatomy scan will also show in 20 weeks and that is a standard test for AMA people, as well. 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Nipt including gender was inconclusive, and Australias largest pathology provider Ziff Davis company a long! Page 2: has anyone had the CVS performed yesterday and did a redraw, and i 'm wondering because. Is still interfering with the test for you in limbo not knowing the fetal and. Not sure who it was why is my nipt test inconclusive nearly as bad as i thought abnormalities are: Down syndrome ( 21! Laboratory technical issues such as Edward 's syndrome a redraw, and accurate methods to the... Them all over the place here noninvasive prenatal testing ( NIPT ) has become a popular screening test for most. Are up to 99 % accurate for chromosomal abnormalities other than Down 's, such as low fetal and. Your NIPT result caused no result prenatal screening method inherited mutations with this personally, but Ive heard. Common questions we are part of Sonic Healthcare, an acknowledged world leader the!

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